When it comes to medicine, most people prefer pills to needles. But many drugs aren't properly absorbed when taken in pill form. Now, researchers may have solved the problem: a digestible pill, covered with tiny needles, that injects drugs directly into your stomach lining.

Above: A schematic drawing of a microneedle pill with hollow needles | Image Credit: Christine Daniloff/MIT, based on images by Carl Schoellhammer and Giovanni Traverso

The novel drug delivery system is the result of a collaboration between researchers at MIT and Massachusetts General Hospital. The concept for the pill is described in the video below, but the gist is as follows: A capsule is coated first with tiny needles, then a pH-sensitive coating. The coating not only makes it possible to swallow the pill, it also dissolves away in the low-pH environment of the stomach. When it does, the needles are exposed. Intestinal contractions carry the pill through the digestive tract while applying pressure to an internal drug reservoir. In this way, the drug is delivered via the needles into the intestinal wall, where it can be absorbed. Such a system could one day replace injections of medications like insulin, which are too big to be absorbed via the stomach, and prone to decomposition by gastrointestinal molecules, to be taken orally:

In the latest issue of the Journal of Pharmaceutical Sciences, researchers led by chemical engineer Carl Schoellhammer document the potential of the new drug delivery system. Using a pig as a model, the team demonstrated that injection into the intestines is an effective method of insulin-delivery. In a second experiment, the team showed that a pill measuring two centimeters long, 1 centimeter across, and coated in five-millimeter stainless-steel needles could pass safely through the digestive tract of a pig. Future versions of the pill could be coated with needles made of degradable polymers and sugars:


Above: Two versions of the microneedle pill. The pill on the bottom features solid microneedles made from sugars or polymers that could break off and lodge in stomach tissues, where they could dissolve slowly while releasing their payload | Image Credit: Carl Schoellhammer and Giovanni Traverso

[Journal of Pharmaceutical Sciences]

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