The Black Book of Carmarthen, named for the color of its binding and believed location of origin (the Augustinian Priory of Saints John the Evangelist and Teulydog in Carmarthem), is the oldest surviving manuscript written in the Welsh language.
Charles Darwin wasn't just a writer and a naturalist; he was also the father of ten children. And when those children got a hold of his manuscript for On the Origin of Species, the did what kids do: they drew all over them.
What happens when a cat sneaks over and pees all over the precious manuscript that you've spent months of your life inscribing? If you're this 15th century monk, you leave a note cursing the cat and move on with your writing.
This page from a 1584 treatise on explosive weaponry reveals two of the 16th century's more mobile methods of destruction: the cat bomb and the bird bomb, apparently used to set buildings on fire. BibliOdyssey has more fiery weapons from this manuscript, the rest of which are safer for friends of felines.
Lewis Carroll's first iteration of Alice's Adventures in Wonderland was a much shorter work titled Alice's Adventures Under Ground. Although the final product is well known for John Tenniel's memorable illustrations, Carroll himself illustrated his original manuscript.