How does toothpaste make orange juice taste bad?Robbie Gonzalez5/22/13 6:20pmFiled to: chemistryscienceexplainerorange juicesodium laurel sulfateslstaste372EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Brush your teeth before downing a glass of orange juice, and you're gonna have a bad time. But why?AdvertisementThere are four main ingredients in most any toothpaste. Water, abrasives, fluoride and detergent. The detergent sodium laurel sulfate (SLS) is known for nerfing sweetness receptors, and clears your mouth of phosphilipids which usually prevent orange juice's bitter molecules from reaching your tongue's bitterness receptors. More more details, check out the ByteSizeScience video above, created by the American Chemical Society.