Don't count on seeing a horrific Little Sister on the big screen any time soon. Gore Verbinski (Pirates of the Caribbean) was supposed to be directing the big-screen BioShock film, but he tells Coming Soon that it's dead in the water. The big issue: the R-rating, coupled with a big budget:
I couldn't really get past anybody that would spend the money that it would take to do it and keep an R rating. Alternately, I wasn't really interested in pursuing a PG-13 version. Because the R rating is inherent. Little Sisters and injections and the whole thing. I just wanted to really, really make it a movie where, four days later, you're still shivering and going, "Jesus Christ!"... It's a movie that has to be really, really scary, but you also have to create a whole underwater world, so the pricetag is high. We just didn't have any takers on an R-rated movie with that pricetag.
He also explains why he thinks this is one example of a movie that really would benefit from being in 3D, because it could help put you on edge.